Table 7. The best candidate models for interactions of gene-gene-smoking duration from MDR analysisa,b.
| Model | Attributes | Bal. Acc.c overall | Bal. Acc. CVd training | Bal. Acc. CV testing | CV consistency | P valuee |
|---|---|---|---|---|---|---|
| MDM2 + PPP1R13L + CD3EAP + smoking-duration | ||||||
| One-locus | Smoking | 0.5708 | 0.5708 | 0.5708 | 10/10 | 0.0020–0.0030 |
| Two-locus | Smoking | |||||
| rs735482 | 0.5831 | 0.5833 | 0.5657 | 8/10 | 0.0040–0.0050 | |
| MDM2 + PPP1R13L + CD3EAP + TP53 + smoking-duration | ||||||
| One-locus | Smoking | 0.5708 | 0.5708 | 0.5708 | 10/10 | 0.0080–0.0090 |
| Two-locus | Smoking | |||||
| rs735482 | 0.5831 | 0.5833 | 0.5657 | 8/10 | 0.0130–0.0140 | |
| MDM2 + TP53 + smoking-duration | ||||||
| One-locus | Smoking | 0.5708 | 0.5708 | 0.5708 | 10/10 | 0.0030–0.0040 |
| Two-locus | Smoking | |||||
| rs1846402 | 0.579 | 0.5807 | 0.557 | 7/10 | 0.0170–0.0180 | |
| Three-locus | Smoking | |||||
| rs2291857 | ||||||
| rs8064946 | 0.6073 | 0.609 | 0.57 | 8/10 | 0.0030–0.0040 | |
| Fourth-locus | Smoking | |||||
| rs1690924 | ||||||
| rs2291857 | ||||||
| rs8064946 | 0.6446 | 0.6486 | 0.5535 | 8/10 | 0.0250–0.0260 | |
a, analyzed by MDR 3.0.3. dev. Jar, data of TP53 from previous study (Yin et al. submitted and revised); b, only list statistical significant models; C, balanced accuracy; d, cross-validation; e, P value based on 1,000 permutation test, statistical significant P value.