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. 2020 Aug;8(15):950. doi: 10.21037/atm-20-2901

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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RACGAP1 is highly upregulated in ESCC. (A,B) mRNA expression of RACGAP1 is significantly upregulated in ESCC tissues compared to healthy tissues, indicated by three microarray datasets from GEO (A) as well as RNA-seq data from TCGA data (B). (C) QPCR assay was conducted to validate the upregulation of RACGAP1 mRNA level in ESCC tissues (n=96) compared to adjacent healthy tissues (n=20). (D) The Kaplan-Meier curves showed that the overall survival (OS) time was significantly shorter in the high RACGAP1 expression group. The P value was determined by the log-rank test. (E) Left panel: Western blotting assay shown that the RACGAP1 protein level in ESCC tissues is higher than in matched adjacent healthy tissues. Right panel: statistical results of the grayscale analysis. The P value was determined with a paired t-test. ***, P<0.001.