Figure 3.

Network clustering of autoantibodies in sputum and serum of four groups. (A) Analytic COPD cohort; (B) validation COPD cohort; (C) non-COPD controls; (D) CTD-ILD patients. The size of each node (an autoantibody) is proportional to its weighted degree value. The color of each node represents the corresponding module. Correlation coefficients with P values ≥0.05 were removed. Edges between pairs of nodes represent statistically significant correlations (P<0.05); edges shown in red are statistically significant positive correlations, and edges shown in blue indicate statistically significant negative correlations. The suffix “sp” indicates autoantibodies in sputum; the other autoantibodies are those in serum. COPD, chronic obstructive pulmonary disease; CTD-ILD, connective-tissue disease-associated interstitial lung disease.