Table 3. Correlation coefficients between sputum autoantibody levels and clinical parameters in COPD patients (adjusted by age).
Sputum autoantibodies | FEV1 (%predicted) | CAT | mMRC | Number of exacerbations in the previous year | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
r | P | r | P | r | P | r | P | ||||
Anti-Sm | 0.101 | 0.504 | 0.182 | 0.226 | 0.026 | 0.864 | 0.115 | 0.448 | |||
Anti-P0 | –0.045 | 0.766 | 0.421 | 0.004 | 0.190 | 0.205 | 0.370 | 0.011 | |||
Anti-Ro/SSA | –0.005 | 0.973 | 0.338 | 0.022 | 0.191 | 0.203 | 0.382 | 0.009 | |||
Anti-La/SSB | 0.021 | 0.888 | –0.058 | 0.701 | 0.025 | 0.871 | 0.025 | 0.869 | |||
Anti-Scl70 | –0.083 | 0.584 | 0.041 | 0.787 | 0.167 | 0.266 | 0.174 | 0.246 | |||
Anti-Jo1 | –0.197 | 0.191 | 0.085 | 0.576 | 0.122 | 0.419 | 0.268 | 0.072 | |||
Anti-TPO | 0.244 | 0.103 | –0.118 | 0.435 | –0.169 | 0.262 | –0.182 | 0.227 | |||
Anti-MPO | –0.111 | 0.463 | 0.309 | 0.037 | 0.159 | 0.292 | 0.206 | 0.171 | |||
Anti-PR3 | –0.303 | 0.041 | 0.291 | 0.050 | 0.237 | 0.113 | 0.304 | 0.040 | |||
Anti-U1-SnRNP | –0.006 | 0.969 | 0.352 | 0.016 | 0.157 | 0.298 | 0.367 | 0.012 |
COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; CAT, COPD assessment test; mMRC, modified Medical Research Council Dyspnea Scale; Sm, Smith antigen; P0, ribosomal phosphoprotein P0; Ro/SSA, Ro/Sjögren syndrome type A antigen; La/SSB, La/Sjögren syndrome type B antigen; Scl-70, DNA topoisomerase I; Jo-1, histidyl-tRNA synthetase; U1-SnRNP, U1 small nuclear ribonucleoprotein; TPO, thyroid peroxidase; PR-3, proteinase-3; MPO, myeloperoxidase.