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. 2020 Aug;8(16):986. doi: 10.21037/atm-20-4404

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Expression of SAP130 in lung tissue of IPF patients and control subjects (IHC staining). (A) Representative image of control lung tissues (scale bar: 50 µm) showed SAP130 protein is expressed sparsely in normal alveolar structures. (B) Representative image of lung tissues of an IPF patient (scale bar: 50 µm) showed SAP130 protein is dramatically increased in IPF compared to control. SAP130 localizes diffusely to alveolar epithelial cells adjacent to the areas of mature fibrosis. SAP130, spliceosome-associated protein 130; IPF, idiopathic pulmonary fibrosis; IHC, immunohistochemistry.