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. 2020 Aug;8(16):997. doi: 10.21037/atm-20-5171

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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A PPI network and three significant modules of DEGs. (A) A PPI network of DEGs created by STRING. Circles represent genes, and lines represent PPIs. (B) The most significant module identified by MCODE (score =4). (C) The second most significant module identified by MCODE (score =3.5). (D) The third most significant module identified by MCODE (score =3.429). PPI, protein-protein interaction; DEGs, differentially expressed genes; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins; MCODE, molecular complex detection.