Multimode imaging effect of ICG-CpG@MOF.A. Time series of the tumor near-infrared fluorescence imaging in situ and in organs after tail vein injection for 0 h–48 h. Li: Liver, H: Heart, S: Spleen, Lu: Lung, K: Kidney, T: Tumor. B. Horizontal section and coronal section nuclear magnetic imaging in tumor-bearing mice 2 h after in-situ injection. C. In situ photothermal imaging. D. Photoacoustic imaging of tumor before and after in situ injection. E. In vitro PA images of ICG-CpG@MOF solutions at different concentrations (0, 0.5, 1, 2, 5, and 10 μg/mL respectively).