Scheme 1.

Schematic illustration for A. Synthesis of ICG-CpG@MOF and B. Mechanism of multimodality imaging (photoacoustic, nuclear magnetic, fluorescence imaging) guided synergistic cancer photo-immunotherapy. MIL101-NH₂ is synthesized by heating the mixture of FeCl₃ and 2-amino-terephthalic acid (NH₂-BDC). The carboxyl-activated ICG was then connected to the amino of MIL101-NH₂ through the formation of amido bond. CpG was bound to MIL101-NH₂ by the effect of the porous and electrostatic adsorption. ICG-CpG@MOF enriched in tumor tissues through the EPR effect, and photoimmunotherapy was activated by 808 nm laser.