Table 3. Comparison of clinical characteristics and inflammatory cytokines between hypoxemia non- hypoxemia group in 43 type-55 adenovirus pneumonia.
| Clinical parameters | PF ratio <300 | PF ratio >300 | P value |
|---|---|---|---|
| Number of patients | 6 | 37 | |
| Median age, range | 20.0 [20.0–22.0] | 20.0 [19.0–21.0] | 0.482 |
| Sex (male) | 6 [100] | 37 [100] | – |
| Hospital days | 12.5 [10.0–14.8] | 7.0 [6.0–9.0] | <0.001 |
| Presenting symptom | |||
| Cough | 6 (100.0) | 34 (91.9) | 0.470 |
| Dyspnea | 3 (50.0) | 10 (27.0) | 0.256 |
| Chest pain | 5 (83.3) | 7 (18.9) | 0.001 |
| Fever (≥38.3 °C) | 6 (100.0) | 32 (86.5) | 0.338 |
| Sputum | 5 (83.3) | 30 (81.1) | 0.895 |
| Initial room air saturation (%), mean | 96.0 [90.0–98.0] | 98 [97.0–98.0] | 0.162 |
| Total fever days | 5.0 [4.5–6.5] | 2.0 [2.0–3.0] | <0.001 |
| Initial laboratory findings | |||
| White blood cell count (/μL) | 3,980 [2,585–6,195] | 5,440 [3,840–7,040] | 0.015 |
| Neutrophil count (/μL) | 3,144 [1,934–4,737] | 3,342 [2,312–5,131] | 0.694 |
| Lymphocyte count (/μL) | 664 [494–870] | 1270 [906–1430] | 0.004 |
| Monocyte count (/μL) | 264 [100–442] | 539 [338–868] | 0.015 |
| Hemoglobin (g/dL) | 14.0 [13.6–14.3] | 13.9 [13.6–14.7] | 0.932 |
| Platelet count (103/μL) | 125,330±63,503 | 164,970±48,294 | 0.218 |
| C-reactive protein (mg/dL) | 10.0 [7.2–10.5] | 8.5 [3.5–10.5] | 0.206 |
| Serum cytokine concentration | |||
| IL-6 (pg/mL) | 17.3 [16.7–18.0] | 13.7 [8.4–16.5] | <0.001 |
| IL-8 (pg/mL) | 28.1 [20.0–58.6] | 23.8 [16.7–32.0] | 0.420 |
| TNF-α (pg/mL) | 1.87 [1.61–2.54] | 1.71 [1.47–1.98] | 0.293 |
| IFN- γ (pg/mL) | 103.1 [30.8–157.2] | 19.9 [6.0–41.6] | 0.035 |
| IL-10 (pg/mL) | 7.33 [1.53–13.05] | 1.13 [0.37–3.87] | 0.070 |
| Initial chest radiograph finding | 0.016 | ||
| Unilateral pneumonia | 3 (50.0) | 33 (89.2) | |
| Bilateral pneumonia | 3 (50.0) | 4 (10.8) | |
| Effusion | 4 (66.7) | 4 (10.8) | 0.001 |
dl, deciliter; g, gram; IFN, interferon; IL, interleukin; PF, PaO2/FiO2; TNF, tumor necrosis factor.