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Hazard ratio of age on overall survival by restricted cubic spline. The estimated HR (solid line) with 95% CI (dotted line) for the association between age at diagnosis and OS in 675 patients, based on restricted cubic spline (RCS), was calculated using R package ‘survival’ and ‘rms’. The HR of patient age as a continuous variable was 1.18 (95% CI: 0.91–1.54, P<0.01). HR, hazard ratio; OS, overall survival.
