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. 2020 Aug 5;21:1111–1119. doi: 10.1016/j.omtn.2020.08.001

Figure 5.

Figure 5

Identification of circ_0003738/miR-562/IL-17RA and circ_0003738/miR-490-5p/IFNGR2 Signaling

(A) TargetScan and miRanda showed that miR-562 and miR-490-5p might be the potential targets of circ_0003738. (B) FISH indicated the colocalization between circ_0003738 (red) and miR-562 (green) and miR-490-5p (green) in the cytoplasm of Jurkat cells. (C) TargetScan showing miR-562 and miR-490-5p binding sites in 3′ UTR of IL-17RA and IFNGR2. (D) Quantitative real-time PCR analysis of IL-17RA and IL-17A expression after transfection with miR-562 mimics or inhibitor. Quantitative real-time PCR analysis of IFNGR2 and IFN-γ expression after transfection with miR-490-5p inhibitor or mimics. (E) FISH showed the colocalization between miR-562 and IL-17RA, and colocalization between miR-490-5p and IFNGR2 in the cytoplasm of Jurkat cells. Data are representative of means ± SEMs. ∗p < 0.05; ∗∗p < 0.01.