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. 2020 Jul 28;64(2):205–221. doi: 10.1042/EBC20190074

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© 2020 The Author(s).

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).

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(A) A multiple sequence alignment of the CATD region of CENP-A (H. sapiens) and CENP-A^Cse4 (S. cerevisiae) with the corresponding region of H3 (H. sapiens). Insertions in the L1 loop are colored red. (B) A table summarizing information revealed from published 3D-structures of nucleosomes in complex with CENP-N. A surface representation of the CENP-A nucleosome with the mapped CENP-N footprint in black is shown on the far left. In the surface representation, histones are light gray, DNA is dark gray, CENP-N is green, CENP-C^CR is magenta, the CENP-C^motif is dark red, and the other CCAN components are shown in transparent beige. The CENP-N residues interacting with the CENP-A RG loop are shown as sticks. Positively charged residues (arginines and lysines), interacting with the nucleosomal DNA, are shown in blue.