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. 2020 Aug;9(4):1725–1734. doi: 10.21037/tau-20-1079

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2020 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Mutations of BAP1 are associated with KIRC prognosis and drug selection. (A) Correlation between the BAP1 mutation and mRNA expression. (B) Kaplan-Meier survival curves for KIRC patients stratified by the BAP1 mutation. (C,D) Scattered plot and volcano plot show that multiple cancer cell types with the BAP1 mutation were not significantly inhibited by linsitinib. (E) Reproduction of the GDSC database by excluding cancer of other types showed that KIRC cells with the BAP1 mutation were significantly inhibited by linsitinib. *, P<0.05. GDSC, Genomics of Drug Sensitivity in Cancer; KIRC, kidney renal clear cell carcinoma.