Table 1. Comparison of outcomes of nephroureterectomy by technique.
| Author | Time-frame | Technique | Number of patients | Median follow-up (months) | 5-yr recurrence free survival (%) | 5-yr cancer specific survival rate (%) | Notes |
|---|---|---|---|---|---|---|---|
| Capitanio et al. | 1987–2007 | ONU | 979 | 73 | 76.2 | 73.1 | Patients who underwent LNU were older but had more favorable pathologic staging and less LVI. After adjustment for tumor stage, no significant difference in RFS or CSS based on technique |
| LNU | 270 | 31 | 86.8 | 85.8 | |||
| Walton et al. | 1987–2008 | ONU | 703 | 36 | 73.7 | 63.4 | Patients who underwent LNU were more likely to have renal pelvis tumors, received adjuvant chemotherapy and higher grade tumors. After adjustments, no significant difference in RFS or CSS based on technique |
| LNU | 70 | 17 | 75.4 | 75.2 | |||
| Simone et al. | 2003–2006 | ONU | 40 | 44 | 77.4 | 89.9 | Prospective randomized study demonstrating less mean blood loss and time to discharge with LNU. Overall, no difference in RFS and CSS but in patients with ≥ pT3 tumors, CSS and RFS were in favor of ONU |
| LNU | 40 | 44 | 72.5 | 79.8 | |||
| Lim et al. | 2007–2010 | RANU | 32 | 45 | 68.1 | 75.8 | No comparison with ONU |
| Aboumohamed et al. | 2008–2014 | RANU | 65 | 25 | 57.1 | 69.5 | No comparison with ONU |
| De Groote et al. (29) | 2008–2017 | RANU | 78 | 15 | 53 (4-yr) | Not reported | 4-yr overall survival of 66% |
ONU, open nephroureterectomy; LNU, laparoscopic nephroureterectomy; RANU, robotic assisted laparoscopic nephroureterectomy; LVI, lymphovascular invasion; RFS, recurrence free survival; CSS, cancer specific survival.