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. 2020 Sep 7;21:238. doi: 10.1186/s13059-020-02148-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Analysis of non-synonymous changes and their correlation with viral load in acute patients. a The average non-synonymous variation in codon frequency at every amino acid site of each EBOV protein. b Comparison of the non-synonymous nucleotide substitution frequency in the L protein at positions 572, 986 and 2061, and the P values were calculated with a one-sided Wilcoxon rank sum test. c A two-sided Spearman rank correlation test was used to estimate the correlation of average non-synonymous deviation in viral genomes with viral load (1/Ct) at positions 572, 986 and 2061 in patients who were either hospitalised fatal versus hospitalised survived cases, where the R value is the correlation coefficient ranging in − 1 (strong negative correlation) and 1 (strong positive correlation), and P is P value for this test