Figure 1.

Effects of stimuli after nerve injury in mice and naked mole-rats. (a) Mice (n = 8) developed hypersensitivity to innocuous mechanical stimuli within seven days of spared nerve injury compared to BL, which was maintained for at least four weeks, ***p < 0.001. (b) Like mice, NMRs developed sensitivity to innocuous mechanical touch after nerve injury compared to BL threshold. Threshold measurements differed between sham (n = 16) and SNI (n = 15) animals at every time point beyond baseline, ***p < 0.001. (c) Mice (n = 8) exhibited a larger percent change from BL after nerve injury compared to NMRs (n = 15), **p < 0.01. (d) Neither sex nor status had an effect on the development of hypersensitivity to innocuous mechanical touch in NMRs (male soldier n = 2, female soldier n = 3, male worker n = 5, female worker n = 5; p = 0.404). (e) Both species developed similar reaction patterns to noxious mechanical pinprick over time, p = 0.117. Independent t-tests revealed statistical difference between mice and NMR reaction time at WK4, *p < 0.05. (f) Reaction to an acetone droplet differed between NMR and mice across time points. Independent t-tests showed statistical difference between mice and NMR both at baseline and at every time point after surgery, **p < 0.01. Data plotted as mean ± SEM. BL: baseline; NMR: naked mole-rat; SNI: spared nerve injury; WK: week.