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. 2020 Sep 3;16:1744806920955103. doi: 10.1177/1744806920955103

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Behavioral reaction to chemical activators of cold receptors in surgically naïve animals. (a) Mice (n = 17) exhibited less licking/chewing in the 10 min after intraplantar injection of mustard oil, activator of TRPA1, compared to NMRs (NMR; n = 17), **p < 0.01. (b) In contrast, NMRs (n = 16) displayed little licking/chewing behavior compared to mice (n = 16) in the 10 min after an intraplantar injection of icilin, strong activator of TRPM8, ***p < 0.001. (c and d) Raster plots of time spent licking/chewing (s) after intraplantar mustard oil (c) and icilin (d). NMR: naked mole-rat.