Table 1.
Results of histopathological evaluation of ileum following whole body irradiation with 10 Gy gamma rays and treatment with melatonin or melatonin plus metformin. Histopathological results were scored as 0= normal; 1= mild changes; 2= moderate changes; and 3= severe changes.
| - | Control | MLT | MLT+MET | RAD | RAD+MLT |
RAD+MLT+
MET |
|---|---|---|---|---|---|---|
| Congestion of blood vessels | 0.00 ± 00 | 0.00 ± 00 | 0.00 ± 00 | 2.80 ± 0.45a | 1.50 ± 0.55b | 2.50 ± 0.57 |
| Degenerative changes and necrosis of lamina propria | 0.00 ± 00 | 0.00 ± 00 | 0.00 ± 00 | 2.80 ± 0.45a | 0.60 ± 0.55b | 1.50 ± 0.58b |
| Intestinal mucositis changes | 0.00 ± 00 | 0.00 ± 00 | 0.00 ± 00 | 2.40 ± 0.55a | 0.00 ± 00b | 0.00 ± 00b |
| Inflammatory cells’ infiltration | 0.00 ± 00 | 0.00 ± 00 | 0.00 ± 00 | 2.80 ± 0.45a | 0.00 ± 00b | 0.00 ± 00b |
| Average number of goblet cells | 63.00 ± 1.87 | 64.80 ± 0.75 | 63.20 ± 0.98 | 21.00 ± 1.58a | 42.20 ± 0.80b | 35.75 ± 1.50b |
| Length of villi | 826 ± 64μm | 882 ± 66μm | 835 ± 46μm | 561 ± 42μma | 854 ± 70μmb | 615 ± 39 |