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. 2020 Aug 10;13(16):3526. doi: 10.3390/ma13163526

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The influence of plate structuring on osteogenic differentiation. The gene expression analysis of osteogenic genes after 4 weeks of differentiation of human mesenchymal stem cells. Differentiation of MSCs according to gene expression was successful on polystyrene (plastic), steel, and titanium surfaces, while Collagen 1 expression was not changed after differentiation on titanium plates. OCN (A) and RUNX2 (C) expression was inhibited by all structured plates, while Collagen 1 expression (B) was reduced on structured steel plates only. * (p < 0.05), ** (p < 0.005), *** (p < 0.0005), ns (non-significant).