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. 2020 Aug 15;17(3):569–582. doi: 10.20892/j.issn.2095-3941.2020.0033

Figure 3.

Figure 3

The effects of miR-135a on cancer progression and relevant targets and signaling pathways. (A) The miR-135a could inhibit the progression of cancer by targeting various mRNAs, which led to the inactivation of several pathways, including the PI3K/AKT pathway, JAK2/STAT3 pathway, and NF-κB pathway, as well as the activation of the p38 MAPK pathway and the p53 cancer suppressor gene. (B) The miR-135a can also promote cancer development via the activation of the Wnt/β-catenin pathway and STAT3, and the inactivation of phosphoenolpyruvate carboxykinase.