Figure 4.

ALKBH5 knockdown suppressed malignant behavior of colon cancer partially through NEAT1 in vitro and vivo. A: ALKBH5 knockdown significantly attenuated colon cancer cells proliferation, which was partially rescued by NEAT1 at 96 h; ALKBH5 knockdown significantly inhibited the expression of PCNA, which was partially rescued by NEAT1. B: NEAT1 could abolish the suppression of ALKBH5 knockdown in cell migration. C: ALKBH5 knockdown could obviously enhance cell apoptosis rates in colon cancer cells, which was reversed by NEAT1 obviously; NEAT1 could reverse the suppression of ALKBH5 knockdown in Bcl-2 expression. D, E: NEAT1 could was capable to partly counteract the suppression of si-ALKBH5 in tumor growth. *P<0.05 compared to si-NC, si-ALKBH5+NEAT1 group.