Figure 5.

(A, B) The results of Volcano Plot of differentially expressed genes (DEGs) in TCGA (A) and CGGA (B). The vertical lines demark the fold-change values. The right vertical line corresponds to log2FC>1 change, while the left vertical line corresponds to log2FC<-1 change. The horizontal line marks a -log10 p-value of 0.05. (C) 818 overlapping DEGs were identified in both TCGA and CGGA. (D) Protein-protein interaction (PPI) network analysis by means of running Cytoscape software via the STRING database. The network constructed from 147 genes with combined score >0.4 out of 818 overlapping genes. (E) The top 12 significantly enriched biological processes were ranked including regulation of cell growth and angiogenesis. (F) The top 12 significantly enriched KEGG pathways are shown including Jak-STAT, Toll-like receptor and PI3K-AKT signaling pathway. A p-value <0.05 was regarded as significant.