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. 2020 Aug 15;12(8):4728–4738.

Figure 3.

Figure 3

Circ_0007142 serves as a sponge for miR-186. A. Bioinformatics analysis showed that miR-186 was a potential target of circ_0007142. B. miR-186 level was significantly down-regulated in lung adenocarcinoma cancer tissues compared to adjacent normal tissues. C. miR-186 expression level was obviously lower in 4 cancer cell lines than that in normal cell line. D. The dual-luciferase reporter assay verified the binding with the decreasing fluorescence within miR-186 mimic and circ_0007142 wild type. E. Circ_0007142 expression was negatively correlated with miR-186 expression in cancer tissues. F. CCK-8 assay revealed that miR-186 inhibitor could rescue the suppression by si-circ_0007142 in the proliferation of two cells. G. After cells were transfected with si-circ_0007142, miR-186 expression was significantly up-regulated which was enhanced by miR-186 inhibitor. H, I. miR-186 inhibitor could rescue the suppression by si-circ_0007142 in the migration and invasion number of two cells. *P<0.05 compared to BEAS-2B, miR-NC, si-NC group; **P<0.01 compared to BEAS-2B, normal group.