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. 2020 Aug 15;12(8):4728–4738.

Figure 4.

Figure 4

FOXK1 is a direct target of miR-186. A. TargetScan predicted FOXK1 as a potential target candidate of miR-186. B. Luciferase reporter assay validated miR-186 significantly decreased the luciferase activity of wild type (WT) but not the mutant (Mut) 3’-UTR of FXOK1 in lung cancer cells. C, D. FOXK1 expression was significantly increased in cancer tissues and cells. E. A reverse correlation was found between miR-186 and FOXK1 in lung cancer tissues. F. miR-186 overexpression obviously suppressed FOXK1 expression at both mRNA and protein level. *P<0.05 compared to miR-NC, normal group; **P<0.01 compared to BEAS-2B.