Figure 7.

External validation for prognostic value of integrated prediction model in 380 ccRCC patients from FUSCC cohort. A, B. An integrated gene panel was constructed using 10 hub genes (ADAMTS9, C1S, DPYSL3, H2AFX, MINA, PLOD2, RUNX1, SLC19A1, TPX2, TRIB3), which may serve as an independent panel to predict the progression of ccRCC. Kaplan-Meier analysis revealed significant associations of mRNA levels with DFS (P<0.0001) and OS (P<0.0001). C. ROC curve analysis indicated the ability of the gene model to predict metastasis (AUCs of the integrated model were 0.758 for OS and 0.772 for DFS).