Table 1.

Functional roles of 10 prognostic hub genes

No.	Gene symbol	Full name	Function
1	ADAMTS9	A Disintegrin And Metalloproteinase With Thrombospondin Motifs 9	Pathway: Metabolism of proteins and O-linked glycosylation.
			GO: Metalloendopeptidase activity and endopeptidase activity.
2	C1S	Complement C1s	Pathway: Immune response Lectin induced complement pathway and Creation of C4 and C2 activators.
			GO: Calcium ion binding and serine-type endopeptidase activity.
3	DPYSL3	Dihydropyrimidinase Like 3	Pathway: Semaphorin interactions and Developmental Biology.
			GO: Hydrolase activity and phosphoprotein binding.
4	H2AFX	H2A Histone Family Member X	Pathway: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and ATM Pathway.
			GO: Sequence-specific DNA binding and enzyme binding.
5	MINA	MYC-Induced Nuclear Antigen	Pathway: Validated targets of C-MYC transcriptional activation and Chromatin organization.
6	PLOD2	Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 2	Pathway: Collagen chain trimerization and Lysine degradation.
			GO: Oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
7	RUNX1	Runt Related Transcription Factor 1	Pathway: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers.
			GO: DNA-binding transcription factor activity and protein homodimerization activity.
8	SLC19A1	Solute Carrier Family 19 Member 1	Pathway: Metabolism of water-soluble vitamins and cofactors and Antifolate resistance.
			GO: Oxidoreductase activity and folic acid transmembrane transporter activity.
9	TPX2	Targeting Protein For Xklp2	Pathway: Gene Expression and Cell Cycle, Mitotic.
			GO: GTP binding and protein kinase binding.
10	TRIB3	Tribbles Pseudokinase 3	Pathway: Class I MHC mediated antigen processing and presentation and RET signaling.
			GO: Transferase activity, transferring phosphorus-containing groups and protein kinase binding.