Figure 1.

ORs for rare and singleton variants for different variant classes. Each dot represents the OR generated by the generalised linear model (glm) given with their 95% CIs (as horizontal lines, for loss of function only the left part of the interval). The values on top of each point represent the corrected p value from the glm model (p_glm) and the empirical p value (p_emp) from the Wilcoxon rank-sum test, separated by ‘/’. If both the corrected p values were below 0.05, they are highlighted in red with an ‘*’ on top.