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. 2020 Jan 24;57(9):610–616. doi: 10.1136/jmedgenet-2019-106640

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Proposed model of affected signalling and tissues in FHM. We found that following tissues and pathways are affected: (A) Nerve junction with release of neurotransmitters, which act as ligands on the LGICs and subsequently leads to downstream signalling in the postsynapse. (B) Junction between postsynapse and smooth muscle cell. GPCRs are expressed in both cell types and can lead to downstream signalling in both cell types as well. FHM, familial hemiplegic migraine; GPCR, G protein-coupled receptor; LGIC, ligand-gated ion channel.