Table 1.

Patient groups and rare variant groups

Patient groups analysed	Rare variant group	Difference (%)	Adjusted P value
FHM versus familial migraine	Functional variants	15.1	1.46e-6
FHM versus sporadic migraine	Functional variants	17.5	5.2e-10
Sporadic migraine versus familial migraine	Functional variants	2.2	0.0076
FHM versus familial migraine	Frameshift indels	13.2	0.00099
	Non-frameshift indels	2.3	1
	Stop codon indels	−0.5	1
	Non-synonymous SNP	11.8	0.0038
FHM versus sporadic migraine	Frameshift indels	20	5.19e-13
	Non-frameshift indels	4.4	0.13
	Stop codon indels	2.1	1
	Non-synonymous SNP	20.1	1.60e-13

The results from the MCMCgrm area under the curve analysis are listed in columns 3 and 4, where the differences (%) between groups are listed, together with the adjusted p values, respectively.

FHM, familial hemiplegic migraine; SNP, Single Nucleotide Polymorphism.