Table 4.
Characteristics of participants in RUN DMC, stratified by median WMH scores
| Low severity (n = 166) | Moderate-high severity (n = 165) | P | |
| Age | 65.5 (6.7) | 72.6 (8.1) | <0.001 |
| Sex, female (%) | 66 (39.8) | 68 (41.2) | 0.875 |
| Education | 0.009 | ||
| Low (%) | 9 (5.4) | 21 (12.7) | |
| Medium (%) | 88 (53.0) | 97 (58.8) | |
| High (%) | 69 (41.6) | 47 (28.5) | |
| Hypertension (%) | 122 (73.5) | 143 (86.7) | 0.004 |
| Diabetes (%) | 20 (12.7) | 28 (17.5) | 0.305 |
| Hypercholesterolaemia (%) | 70 (44.6) | 91 (56.9) | 0.038 |
| Smoking | 0.029 | ||
| Never (%) | 53 (31.9) | 42 (25.5) | |
| Ex (%) | 85 (51.2) | 107 (64.8) | |
| Current (%) | 28 (16.9) | 16 (9.7) | |
| BMI, kg/m2 | 27.9 (4.4) | 27.8 (4.8) | 0.89 |
| Dementia | 5 (3.0) | 28 (17.0) | <0.001 |
| Apathy | 25.5 (6.4) | 29.4 (9.3) | <0.001 |
| Depression | 14.5 (3.6) | 14.3 (4.7) | 0.714 |
| MMSE | 28.6 (1.5) | 27.6 (2.4) | <0.001 |
| PS index | −1.1 (0.7) | −1.4 (0.7) | <0.001 |
| IADL | 7.9 (0.3) | 7.5 (1.3) | <0.001 |
BMI, body mass index; IADL, Instrumental Activities of Daily Living; MMSE, Mini Mental State Examination; PS, processing speed; RUN DMC, Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort; WMH, White matter hyperintensity volume.