Skip to main content
. 2020 Aug 20;37:101692. doi: 10.1016/j.redox.2020.101692

Fig. 2.

Fig. 2

GR gene delivery abolished Klotho deficiency induced renal structural and functional damage. (A) Representative photomicrographs and quantitative analysis of PAS-stained kidney sections. Arrows indicate PAS-positive mesangial material (pink). Relative mesangial matrix area is expressed as PAS-positive mesangial matrix per total glomerular tuft cross-sectional area. An average value was obtained from analyses of 20 glomeruli per mouse. (B) Representative photomicrographs of H&E-stained kidney sections. Arrows indicate tubular cast (protein) formations. Semi-quantitative analysis of tubular cast formation in medulla is expressed as area fraction. Scale bars, 50 μm. (C) Plasma urea concentration. (D) Plasma creatinine concentration. (E) Urinary albumin (normalized to urinary creatinine). n = 4–6 mice/group. *P < 0.05 **P < 0.01 vs WT + PBS; +P < 0.05 ++ P < 0.01 vs KL+/- + AAV-GFP. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)