Table 1.

PET Radio Tracers in Leukemia as well as Their Main Advantages and Disadvantages.

PET radiotracers	Advantages	Disadvantages
18F -FDG	18F-FDG can detectvarious hematologic neoplasms due to altered glucose consumption. Its half-live is appropriate for clinical use and it is inexpensive tomanufacture reliably	Sometimes it is difficult to dis differentiate benign lesions such as inflammation from malignantdisease. And it may not be able to detect malignant involvement in areas of high HueD_Ref18glucose metabolism such as the meninges or the pericardium
18F-FLT	18F-FLT PET may reduce the false-positive manifestations due to infection or inflammation, and it may be appropriate for the detection of meningeal diseases because of the negligible background uptake in the brain and skull.	18F-FLT uptake in bone marrow is unable to demonstrate leukemia infiltration due toit may be caused byboth neoplastic and normal hematopoietic cells
68Ga-Pentixafor	68Ga-Pentixafor may possibly be useful for detection, characterization, andtreatment response assessment in CLL patients	68Ga-Pentixafor reflects the CXCR4 expression, and only used in CXCR4-based CLL
11C-choline	The negligible uptake of 11C-Choline in the normal brain may be helpful for the diagnosis of extramedullary AL in brain	11C-Choline was inappropriate for routine clinical use because of the rapid in vivo degradation and short half-life of 11C