Table 5.
Biochemical parameters of rats fed with CT or HF for 15 weeks and treated with HPβCD/A-1317 or HPβCD/Ang-(1–7) during the last 7 weeks of the diet.
| Parameters | Experimental Groups | |||||
|---|---|---|---|---|---|---|
| CT/E | CT/Ang-(1–7) | CT/A-1317 | HF/E | HF/Ang-(1–7) | HF/A-1317 | |
| Leptin (ng/dl) |
5.25 ± 1.35 | 5.55 ± 1.14 | 7.65 ± 1.42 | 19.40 ± 1.40* | 6.66 ± 0.63# | 4.92 ± 0.27# |
| Total cholesterol (mg/dl) | 40.2 ± 3.2 | 51.8 ± 3.5 | 47.2 ± 1.9 | 74.5 ± 7.2* | 55.9 ± 5.2 | 50.5 ± 5.6# |
| Triacylglycerol (mg/dl) |
37.2 ± 4.9 | 48.1 ± 4.9 | 49.1 ± 5.0 | 68.2 ± 5.9* | 40.7 ± 4.5# | 43.4 ± 7.9# |
| ALT (U/L) |
66.6 ± 2.0 | 75.6 ± 15.0 | 64.1 ± 4.5 | 126.3 ± 28.1* | 72.6 ± 3.6 | 62.7 ± 1.6# |
| AST (U/L) |
174.9 ± 13.5 | 133.4 ± 19.8 | 140.2 ± 12.6 | 219.4 ± 17.6 | 171.3 ± 17.6 | 151.8 ± 6.4# |
| Creatinine (mg/dl) |
0.575 ± 0.04 | 0.637 ± 0.03 | 0.600 ± 0.02 | 0.675 ± 0.02 | 0.575 ± 0.02 | 0.588 ± 0.01 |
| Albumin (g/dl) |
3.34 ± 0.08 | 3.47 ± 0.06 | 3.30 ± 0.10 | 3.46 ± 0.06 | 3.47 ± 0.08 | 3.32 ± 0.10 |
| Total proteins (g/dl) |
8.06 ± 0.12 | 7.71 ± 0.49 | 6.65 ± 0.90 | 7.32 ± 0.10 | 7.21 ± 0.13 | 7.49 ± 0.18 |
| n | 8 | 8 | 8 | 8 | 8 | 8 |
*p < 0.05 compared to CT/E group. #p < 0.05 compared to HF/E group. (ANOVA two way followed by Tukey’s test), expressed as mean values ± standard error of the mean. n = number of animals.