Figure 1.
Forest plot of mean difference between the PDR and control groups and corresponding 95% confidence intervals (CIs) for proteins identified in vitreous specimens using the PEA platform. Protein levels are measured in NPX units. Results are ranked by magnitude of difference for selected top 13 proteins with FDR-P < 0.05. Unequal variance by group (PDR vs. control) was used for calculating the t-test statistic. Assay panels: IO, immuno-oncology (control, n = 17; PDR, n = 20); IN, inflammation (control, n = 17; PDR, n = 20); DE, development (control, n = 17; PDR, n = 20). Protein levels were higher in the vitreous of diabetic patients with proliferative diabetic retinopathy when compared to non-diabetic controls, suggesting potential vitreous biomarkers for diabetic retinopathy.