Table 1.
Hemodynamic characterization of CatA transgenic mice in the working heart apparatusa
| Parameter | Value(s) for: |
p value | |
|---|---|---|---|
| WT (n = 5) | CatA-TG (n = 5) | ||
| EF (%) | 51.4 ± 19.2 | 51.4 ± 6.3 | 0.998 |
| LVEDV (µl) | 50.8 ± 5.8 | 61.9 ± 6.2 | 0.018 |
| LVESV (µl) | 25.2 ± 12.0 | 29.8 ± 3.4 | 0.434 |
| SV (µl) | 25.6 ± 7.5 | 32.1 ± 6.3 | 0.172 |
| HR (bpm) | 397 ± 16 | 402 ± 41 | 0.812 |
| dP/dt max (mmHg/s) | 4980.8 ± 1782.0 | 4913.6 ± 565.0 | 0.937 |
| dP/dt min (mmHg/s) | −3446.6 ± 782.3 | −3670.8 ± 493.4 | 0.602 |
| CO (µl/min) | 10.2 ± 3.1 | 13.0 ± 3.2 | 0.206 |
| Tau-weiss (ms) | 14.2 ± 4.2 | 11.9 ± 1.9 | 0.298 |
| Endsystolic pressure (mmHg) | 67.6 ± 6.4 | 70.9 ± 4.7 | 0.381 |
| Enddiastolic pressure (mmHg) | 7.7 ± 3.5 | 7.6 ± 2.5 | 0.952 |
a Cardiac function was characterized in six-month-old CatA transgenic mice (CatA-TG) and their wild-type littermates (WT) using an isolated working heart apparatus. Abbreviations: ejection fraction (EF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), stroke volume (SV), heart rate (HR), LV contractility (dP/dtmax), relaxation (dP/dtmin), and cardiac output (CO). All values are presented as means ± S.D.