Skip to main content
. 2020 Jun 30;295(36):12573–12587. doi: 10.1074/jbc.RA120.014357

Figure 1.

Figure 1.

MPE reduces blood glucose in db/db mice and maintains blood glucose in HFD-induced obese mice by increasing insulin secretion. A and B, results from db/db mice; C–F, results from HFD-induced obese mice. A and B, weekly fasting blood glucose levels (A) and insulin levels (B) in db/db mice treated with 400 mg/kg MPE, 800 mg/kg MPE, or control after 4 weeks of force-feeding. C, weekly fasting blood glucose levels in HFD-induced obese mice treated with 400 mg/kg MPE, 800 mg/kg MPE, or control after 4 weeks of force-feeding. D, OGTT (glucose at 1 g/kg body weight) after 4 weeks of treatment with MPE and control in HFD-induced obese mice. E and F, AUC of blood glucose during OGTT (E) and plasma insulin levels measured at different time points during OGTT (F) in HFD-induced obese mice. Data are presented as mean ± S.E. (error bars) with individual data points in the histogram (db/db mice: n = 7; HFD-induced obese mice: n = 8). #, 800 mg/kg MPE versus db/db control; *, 400 mg/kg MPE versus db/db control. # or *, p < 0.05; ## or **, p < 0.01.