Table II.
Physicochemical Parameters as Morphology, Particles and Pores Size, Surface Charge and Encapsulation Efficiency (EE% of the Engineered MSNs-Based Nanocarriers for Infectious Diseases Treatment
| Carrier/morphology | Encapsulation efficiency (%) | Particle size (nm) | Pores size (nm) | Zeta potential (mV) | References |
|---|---|---|---|---|---|
| Spherical MSNs | 26.8 and 22.5, respectively | 40 and 100, respectively | 8 to 9 | -20 and -16.9, respectively | (110) |
| Spherical MCM-41-like MSNs | --- | 150 | --- | -25 | (111) |
| Spherical MSNs-MCM-41, modified (vinyl groups) MSNs-MCM-41 and spherical MSNs-MCM-48 | 20 | Modified and non-modified MSNs-MCM-41: ~60 and MSNs-MCM-48:~46 | MCM-41 types: 2.5-3.1 and MCM-48 type: 2.5-9 | --- | (112) |
| Spherical MSNs | --- | 80 | --- | -26.7 | (113) |
| Spherical MSNs | --- | 210 | 2.4 | --- | (114) |
| Rod shaped HMSNs with large cone-shaped pores and small cone-shaped pores | 35 and 5, respectively | Length and width of 400 and 200, respectively, for both nanosystems | 40 and 3, respectively | --- | (115) |
| Spherical MSNs-MCM-41 | --- | 200-400 | 1.75 to 2.98 | --- | (116) |
| MSNs-SBA-16 and MSMs-SBA-16/hydroxyapatite (HA) | 28 to 31, respectively | --- | 3.4 and 3.8, respectively | -56 and 2.9, respectively | (117) |
| Spherical MSNs | 5.9 to 26.8 | 100 | 2.8 | -21.2 | (118) |
| Spherical and spherical modified MSNs | 7.8 | ~150 | 2.4 | -36.4 for non-modified MSNs and +31.8 to +37.4 for modified MSNs | (119) |
| Spherical MSNs-supported Ag-Bi nanoparticles | --- | 200-240 | 3.4-4.8 | --- | (120) |
| Spherical MSNs with large cone-shaped pores | Ag: 2 and DNase I: 32 | 200 | 42-43 | --- | (121) |
| Spherical modified magnetic MSNs | 10.7 | 240 | 3 | -5.32 | (122) |
| zSpherical MSNs-MCM-41 | --- | 150-300 | 2 | MSNs: -45 and MSNs-Ag: +48 | (123) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | --- | 122-220 | 1.9-2.4 | MSNs: -30 and modified MSNs: +5 to +25 | (124) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | 36 | 182 | --- | -30 | (125) |
| Spherical MSNs and spherical modified MSNs | 11to 40 | ~72 | 3.3-4 |
MSNs: −22.9 and modified MSNs: Aminated MSNs: +19 Carboxyl functionalized MSNs: -53 |
(126) |
| SBA-15 and modified SBA-15 | 93-98 | 100-300 |
SBA-15: 7 And modified SBA-15: 6-6.2 |
--- | (127) |
| Spherical MSNs-MCM-48 and spherical modified MSNs-MCM-48 | 27-31.5 | 150-600 | 3.2 | MSNs-MCM-48: -28 to -34 and modified MSNs-MCM-48: +30 to +63 | (128) |
| modified porous silicon nanoparticles (UnTHCPSi NPs) | --- | 176-184 | --- | -25.5 | (129) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | --- | 90 | --- | --- | (130) |
| Hollow oblate MSNs and modified hollow oblate MSNs | 56-64 | Average long-axis length of ~200 and a short-axis width of ~100 | 3.3-3.7 | --- | (131) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | --- | ~50 and ~100 | ~2 | MSNs-MCM-41: -26 to -29 and modified MSNs-MCM-41: +38 to +42.5 | (132) |
| Spherical MSNs and spherical modified MSNs | --- | 100-130 | 2.5 | MSNs: -7 to -10.5 and modified MSNs: +30 to +39 | (133) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | Up to ~70 | 100 | ~2 |
Phosphonate silane-modified MCM-41: -46.3 and amine-silane modified MCM-41: 38.8 |
(134) |
| Spherical modified MSNs | --- | 117 | 3.8 | +36 | (135) |
| Spherical MSNs | Up to ~35 | 38.8 | ~7 | -33 | (136) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | --- | 110 | 3.3 | MSNs-MCM-41: -21 and modified MSNs-MCM-41: +45.5 | (137) |
| Spherical MSNs | 83 | 100 to 105 | --- | +32 to +30 | (138) |
| Mesoporous silica whiskers-SBA-15 and modified mesoporous silica whiskers-SBA-15 | 62.6 to 71.4 | 50 | 6 | --- | (139) |
| Spherical MSNs-MCM-41 and spherical modified MSNs-MCM-41 | Up to 42 and 63% | 39-91 | 2.5 | MSNs-MCM-41: -12 and modified MSNs-MCM-41: +32.5 to +33.6 | (140) |
| Spherical MSNs and spherical modified MSNs | 58.5 | 500 | 2 | --- | (141) |
| Spherical MSNs-MCM-41 | --- | 100 | 3-3.5 | --- | (142) |
| Spherical MSNs | 10.7 | 20-40 | 2.5 to 3.1 | --- | (143) |
| Spherical MSNs | --- | 400 | ~7.6 | --- | (144) |
| Spherical MSNs and spherical modified MSNs | 2 | 75-88 | 2.6-3.5 | MSNs: -25 and modified MSNs: -0.26 | (145) |
| Spherical MSNs and spherical modified MSNs | --- | 150-200 | 2 | MSNs: -39.6 and modified MSNs: -29.5 | (146) |
| Spherical MSNs and spherical modified MSNs | 30-34 | 100-150 | 2 | MSNs: -28.8 to -44.1 and modified MSNs: -32 to -40 | (147) |
| Spherical MSNs and spherical modified MSNs | --- | 354-571 | --- | -11.2 to -20.5 (in PBS) | (54) |
| Spherical HMSNs | 15 | 200 | --- | --- | (148) |