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. 2020 Jul 6;44(5):645–654. doi: 10.1093/femsre/fuaa027

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© The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Figure 3. — Summary of known and hypothesized interactions between C. albicans and mucins. (A) Known interactions. These include the suppression of C. albicans adherence, filamentation, biofilm formation and secreted protease production in the presence of mucins. Several C. albicans genes encoding important virulence processes are known to be downregulated in the presence of mucins, including ALS1 and ALS3 (adherence); EFG1, ALS3, ECE1 and HWP1 (filamentation); BCR1, EFG1 and NDT80 (biofilm formation); and SAP5 and SAP2 (proteolytic degradation). (B) Hypothesized interactions. C. albicans adhesins may directly bind to a mucin monomer at the C-terminus of the PTS domain and/or at a glycan monosaccharide.