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. 2020 Jun 4;44(5):538–564. doi: 10.1093/femsre/fuaa021

Table 1.

LAB bacteriocins that target the cell wall.

Bacteriocin Producer Class Mode of action References
Nisin L. lactis Ia Elongated lanthipeptide type I (LanBC modified) Binding to lipid II + pore formation Brötz et al. 1998
Lacticin 481 L. lactis Ia Globular lanthipeptide type II (LanM modified) Binding to lipid II + PG transglycosylation inhibition Knerr et al. 2012
Salivaricin A S. salivarius Ia Globular lanthipeptide type II (LanM modified) Low affinity binding to lipid II Geng et al. 2018
Salivaricin B S. salivarius Ia Globular lanthipeptide type II (LanM modified) Accumulation of PG soluble precursors Barbour et al. 2016
Plantaricin C L. plantarum Ia Globular lanthipeptide type II (LanM modified) Binding to lipid II + pore formation (strain dependent) Wiedemann et al. 2006a
Lacticin 3147 L. lactis Two-peptide lantibiotic type II (LanM modified) Binding lipid II by LctA1 + pore formation LctA2 Wiedemann et al. 2006b
Lcn972 L. lactis IId, non-modified Lipid II binding, putative co-target Martínez et al. 2008
Enterolysin A E. faecalis III, bacteriolysin Endopeptidase (stem and interpeptide bridge) Khan et al. 2013
Zoocin A S. equi III, bacteriolysin D-alanyl-L-alanine Zn2+‐metallopeptidase Gargis et al. 2009b
Millericin B S. milleri III, bacteriolysin Endopeptidase (stem and interpeptide bridge) Beukes et al. 2000
Bac41 E. faecalis III, two-component bacteriolysin D-isoglutamyl-L-lysine endopeptidase (BacL1) Kurushima et al. 2013