TABLE 2.
Associations between body mass index (BMI) trajectories and prostate cancer risk
| BMI trajectories | Controls | Cases | |||||
|---|---|---|---|---|---|---|---|
| n = 829 (%) | All | Low and intermediate a | Aggressive b | ||||
| n = 781 (%) | OR [95% CI] c | n = 593 (%) | OR [95% CI] c | n = 176 (%) | OR [95% CI] c | ||
| Stable normal BMI | 302 (36.5) | 282 (36.1) | 1.00 reference | 218 (36.8) | 1.00 reference | 58 (33.0) | 1.00 reference |
| Normal BMI to overweight | 239 (28.8) | 221 (28.3) | 1.04 [0.80‐1.35] | 171 (28.8) | 1.03 [0.78‐1.37] | 48 (27.3) | 1.11 [0.71‐1.74] |
| Growing overweight | 194 (23.4) | 187 (23.9) | 1.03 [0.78‐1.36] | 137 (23.1) | 0.96 [0.71‐1.30] | 46 (26.1) | 1.27 [0.80‐2.00] |
| Normal BMI to obesity | 64 (7.7) | 58 (7.4) | 0.98 [0.64‐1.49] | 46 (7.8) | 1.05 [0.67‐1.63] | 12 (6.8) | 0.81 [0.36‐1.81] |
| Overweight to obesity | 30 (3.6) | 33 (4.2) | 1.05 [0.60‐1.86] | 21 (3.5) | 0.81 [0.42‐1.54] | 12 (6.8) | 2.16 [1.00‐4.66] |
a
Gleason ≤ 7 (3 + 4).
b
Gleason ≥ 7 (4 + 3).
c
ORs adjusted for age, family history of cancer at first degree, ethnicity.