Table 1.

Staging at diagnosis and clinical course for this patient cohort

Sample ID	Diagnosis at time of plasma collection	Left eye ICRB (COG)	Right eye ICRB (COG)	Optic Nerve involvement	Choroid involvement	Anterior Chamber involvement	Extra‐ocular extension	Retinal Detachment	Increased intra‐ocular pressure	Buphthalmia	Iris neovascularization	Treatment prior to plasma collection	Development of bilateral disease a	Development of metastatic disease a	RB1 Clinical Germline Testing
P01	Unilateral	E	N/A	No	No	No	No	Yes	No	No	Yes	No	Yes	No	Heterozygous RB1 c.1072C > T in exon 11
P23	Unilateral	N/A	E	No	Yes	No	No	Yes	No	No	Yes	No	No	Yes	NA
P11	Unilateral	N/A	E	Yes	Yes	No	No	Yes	No	No	Yes	No	No	Yes	Mosaic del24‐26
P03	Unilateral	E	N/A	No	No	No	No	Yes	No	No	No	No	No	No	Negative
P21	Unilateral	E	N/A	No	No	Yes	No	No	No	No	No	No	No	No	Negative
P22	Unilateral	E	N/A	No	No	No	No	Yes	No	No	Yes	No	No	No	Negative
P26	Unilateral	N/A	E	No	Yes	No	No	Yes	Yes	No	Yes	No	No	No	Negative
P24	Unilateral	N/A	E	No	No	Yes	No	No	No	No	No	No	No	No	NA
P16	Unilateral	E	N/A	Yes	No	No	No	Yes	Yes	No	Yes	No	No	Yes	Negative
P19	Unilateral	N/A	E	Yes	Yes	Yes	No	Yes	Yes	No	Yes	Yes	No	No	NA

Abbreviations: COG, Children's Oncology Group; ICRB, International classification of retinoblastoma.

^aClinical status of patients in cohort through March 2020.