TABLE 4.
Construct validity—Hypothesis 1 “Prevalence and intensity of all symptoms will increase with progression of disease”
|
Prevalence—N (%) USD score ≥3 |
P‐value a |
Intensity— median [IQR] |
P‐value b | |||
|---|---|---|---|---|---|---|
|
Chemotherapy N = 1919 |
Symptom directed palliation only N = 224 |
Chemotherapy N = 1919 |
Symptom directed palliation only N = 224 |
|||
| Pain | 452 (24) | 100 (45) | <.0001 | 1 [0‐3] | 3 [1‐6] | <.0001 |
| Sleeping problems | 539 (29) | 117 (53) | <.0001 | 1 [0‐4] | 4 [1‐7] | <.0001 |
| Dry mouth | 466 (25) | 155 (70) | <.0001 | 0 [0‐3] | 5 [2‐8] | <.0001 |
| Dysphagia | 318 (17) | 62 (28) | <.0001 | 0 [0‐2] | 1 [0‐4] | <.0001 |
| Anorexia | 614 (33) | 153 (72) | <.0001 | 1 [0‐5] | 6 [3‐8] | <.0001 |
| Abnormal stool | 548 (30) | 131 (64) | <.0001 | 1 [0‐5] | 5 [2‐8] | <.0001 |
| Nausea | 232 (12) | 55 (25) | <.0001 | 0 [0‐1] | 0 [0‐3] | <.0001 |
| Dyspnea | 141 (8) | 69 (31) | <.0001 | 0 [0‐1] | 1 [0‐4] | <.0001 |
| Fatigue | 779 (41) | 165 (74) | <.0001 | 3 [0‐5] | 6 [3‐8] | <.0001 |
| Anxiety | 356 (19) | 77 (36) | <.0001 | 0 [0‐3] | 1 [0‐5] | <.0001 |
| Depressed mood | 308 (17) | 79 (37) | <.0001 | 1 [0‐3] | 3 [1‐6] | <.0001 |
| Well‐being | NA | NA | 1 [0‐4] | 4 [1‐7] | <.0001 | |
Abbreviations: IQR, inter quartile range; NA, not applicable.
a
Chi square.
b
Mann‐Whitney U