Fig. 1.

panel A-B-C-D.

Panel A-B: multivariable logistic-regression analysis showing independent overall (panel A) and by group (panel B) predictors of in-hospital death.

Panel C: Kaplan–Meier curves depicting mortality rates for OAC patients who were or were not switched to heparin during hospitalization. Log rank p for every group: No HEP/No AHRF vs No HEP/AHRF p < 0.001; No HEP/No AHRF vs HEP/No AHRF p < 0.585; No HEP/No AHRF vs HEP/AHRF p < 0.001; No HEP/AHRF vs HEP/No AHRF p < 0.001; No HEP/AHRF vs HEP/AHRF p < 0.001; HEP/No AHRF vs HEP/AHRF p < 0.001.

By group hazard ratios: No HEP/No AHRF 0.215 (CI 0.125–0.371); HEP/No AHRF 0.196 (CI 0.117–0.330); No HEP/AHRF 6.439 (CI 4.668–8.882); HEP/AHRF 0.869 (CI 1.367–2.557). All p < 0.01.

Panel D: Kaplan–Meier curves depicting mortality rates for patients who were or were not treated with heparin during hospitalization in the presence or absence of AHRF. Hazard ratio for switching from OACs to HEP: 0.213 (CI 0.079–0.575, p < 0.001).

Abbreviations

AHRF: acute hypoxemic respiratory failure

CAD: coronary artery disease

CI: confidence interval

CKD: chronic kidney disease

COPD: chronic obstructive pulmonary disease

HCQ: hydroxychloroquine

HEP: heparin

HF: heart failure

LPV/RTV: lopinavir/ritonavir

OAC: oral anticoagulant

P/F: PaO2/FiO2 ratio

TCZ: tocilizumab

ys: years.