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. 2020 Sep 8;104:104269. doi: 10.1016/j.bioorg.2020.104269

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 3 — The life cycle of SARS-CoV-2. ACE-2: Angiotensin converting enzyme-2, TMPRSS2: Transmembrane protease serine 2, PLpro: Papain-like protease, 3-CLpro: 3-Chymotrypsin-like protease, ORF1ab: Open reading frame 1ab, PP1ab: Polyprotein 1ab, nsp: non-structural protein, S: spike protein, E: Envelope protein, N: Nucleocapsid protein, M: Membrane protein, ERGIC: Endoplasmic reticulum-Golgi intermediate compartment.