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. 2020 Jul 25;472(10):1507–1519. doi: 10.1007/s00424-020-02440-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Expression of ion channels in porcine airway epithelial cells. a Expression of CFTR and TMEM16A (green fluorescence) in airways from newborn CFTR+/+ and CFTR−/− piglets. In WT lungs, CFTR is expressed predominately in submucosal glands (SG). Some expression is found in the surface epithelium (SE). No expression of CFTR is detected in CFTR−/− lungs. In CFTR+/+, TMEM16A is expressed in SE and SG at low level but appears somewhat upregulated in lungs of CFTR−/− animals. Cilia (acetylated tubulin, red) and nuclei (DAPI). About 20–25 images of each n = 3 CFTR−/− and CFTR+/+ animals were examined. b Analysis of mRNA expression for TMEM16A, TMEM16F, CFTR, SLC26A9, and αβγENaC (SCNN1A, SCNN1B, SCNN1G) in airway epithelial cells from newborn CFTR+/+ and CFTR−/− piglets. Mean ± SEM (number of animals/number of reactions). ^#Significant difference when compared to CFTR+/+ (p < 0.05, unpaired t-test)