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. 2020 Jul 25;472(10):1507–1519. doi: 10.1007/s00424-020-02440-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Limited impact of CFTR on pH regulation in piglet airways. a Intraluminal pH measured in bronchioles of CFTR+/+ and CFTR−/− piglets. Per animal, n = 7–24 measurements were taken and pooled. b,c Intracellular pH (pH_i) measured in airway epithelial cells isolated from newborn CFTR+/+ and CFTR−/− piglets. Stimulation with IF had little but significant effects on pH_i of CFTR+/+ cells. d,e Original recordings of pH_i in airway epithelial cells from CFTR+/+ and CFTR−/− piglets. Effect of removal of extracellular Cl⁻ (0 Cl⁻) and addition of I⁻ (0 Cl⁻/I⁻) on pH_i in the absence or presence of IF. f Summaries of the experiments shown in (d,e). n = 3 CFTR+/+ and CFTR−/− animals. Per animal, n = 10–69 measurements were taken and pooled. g,h Expression of CFTR and SLC26A4 in airway epithelial cells from CFTR+/+ and CFTR−/− piglets as detected by RT-PCR. Mean ± SEM (number of animals/number of measurements). *Significant effect of IF and 0 Cl⁻, respectively. ^#significant difference when compared with CFTR+/+, respectively (p < 0.05, ANOVA)