Fig. 6.

Cl⁻ and HCO₃⁻ transport in airway epithelial cells from CFTR+/+ and CFTR−/− piglets. a,b Short circuit Ussing chamber measurements on polarized grown airway epithelial cells from CFTR+/+ and CFTR−/− piglets in the presence of 5% CO₂ and 25 mM HCO₃⁻. Pronounced inhibition of Isc by amiloride (10 μM). c Summaries for the activation and inhibition of Isc by subsequent addition of IF, Bum, and S0859 (S, 30 μM). Mean ± SEM (number of animals/number of filters). *Significant effects of IF, Bum, or S (p < 0.05, paired t-test). Difference when compared with the absence of IF or when compared with CFTR+/+. ^#Significant difference when compared to CFTR+/+ (p < 0.05, unpaired t-test).^