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. 2020 Jul 25;472(10):1507–1519. doi: 10.1007/s00424-020-02440-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Ion currents in airway epithelial cells from CFTR+/+ and CFTR−/− piglets. a,b Ion current overlays and current/voltage relationships obtained in whole cell patch clamp recordings with airway epithelial cells from CFTR+/+ and CFTR−/− piglets. a IBMX/forskolin (IF, 100/2 μM) activated whole cell currents were only detected in cells from CFTR+/+ animals. Currents were inhibited by 30 μM CFTRinh172 (CFinh). b ATP (100 μM) activated whole cells were reduced in CFTR−/− cells. Mean ± SEM (number of animals/number of cells). *Significant effects of IF, ATP, or CFinh (p < 0.05, paired t-test). ^#Significant difference when compared with CFTR+/+ (p < 0.05, unpaired t-test)