Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 16;472(10):1469–1480. doi: 10.1007/s00424-020-02443-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Effects of combined treatment of SNAP and SMN on the survival rate of INS-1 pancreatic cells. a Compared to other doses of SMN, 0.2 nM seemed to be the optimal dose for the survival of INS-1 pancreatic cells (n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001). b SNAP alone produced concentration-dependent reduction in survival rate compared with controls and SNAP combined SMN decreased the survival rate significantly compared with controls (****P < 0.0001; P values refer to differences between effects of SNAP and SNAP combined with SMN compared with controls). c SNAP produced a dose-dependent reduction in the survival rate of INS-1 pancreatic cells and this effect was significantly enhanced in the presence of SMN which reduced the survival rate in a concentration-dependent manner (n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001). P values refer to differences between the effects of SNAP alone and SNAP with SMN on the survival rate of INS-1 pancreatic cells. All values are expressed as ± SE. Abbreviations: INS-1, insulin-producing pancreatic cells; SMN, scopolamine methyl nitrate; SNAP, S-nitroso-N-acetylpenicillamine