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. 2020 Aug 16;472(10):1469–1480. doi: 10.1007/s00424-020-02443-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effects of combined treatment with SNAP and SMN on insulin secretion. a A modest but significant reduction in insulin secretion was observed in response to 2.8 mM, but not 16.7 mM in the presence of SMN. b SNAP produced a concentration-dependent reduction in glucose-induced insulin secretion and these effects were enhanced significantly in the presence of SMN (n = 3, *P < 0.05, ***P < 0.001). All values are expressed as ± SE. Abbreviations: NS, not significant; SMN, scopolamine methyl nitrate; SNAP, S-nitroso-N-acetylpenicillamine